LISBON 4th International Conference on Genetics, Cellular & Molecular Biology (LGCMB-27) scheduled on Feb. 3-5, 2027 Lisbon (Portugal)

LGCMB-27


Genetics & Genomics Cell Biology Developmental Biology & Embryology Evolutionary Biology Microbiology Molecular Biology Bioinformatics & Computational Biology



Call for papers/Topics



 



Topics of Interest for Submission include, but are Not Limited to:



1. Molecular Biology: 



This area focuses on the structure, function, and regulation of macromolecules essential to life, centering on the "Central Dogma" of molecular biology.





  • Nucleic Acid Structure and Biochemistry





    • DNA double helix structure, alternative conformations (A, B, Z DNA)




    • RNA types (mRNA, tRNA, rRNA, snRNA, miRNA, lncRNA) and secondary structures




    • Nucleosome structure, chromatin packing, and histone modifications






  • DNA Replication and Repair





    • Mechanism of semi-conservative replication (initiation, elongation, termination)




    • Replication fork dynamics, DNA polymerases, and okazaki fragments




    • Telomere maintenance and telomerase function




    • DNA damage and repair pathways (Mismatch repair, Base Excision, Nucleotide Excision, Double-Strand Break repair)






  • Transcription and RNA Processing





    • Prokaryotic vs. eukaryotic transcription mechanisms




    • Promoters, enhancers, transcription factors, and RNA polymerases




    • Post-transcriptional modifications: 5' capping, 3' polyadenylation, and constitutive/alternative splicing






  • Translation and Protein Synthesis





    • The genetic code, codon bias, and wobble hypothesis




    • Ribosome structure and the phases of translation (initiation, elongation, termination)




    • Post-translational modifications (phosphorylation, glycosylation, ubiquitination) and protein folding chaperones







2. Genetics: Heredity, Variation, and Regulation



Genetics bridges the gap between molecular mechanisms and organismal traits, exploring how genetic information is passed down and modified.





  • Transmission (Classical) Genetics





    • Mendelian laws of inheritance (segregation, independent assortment)




    • Non-Mendelian inheritance: Incomplete dominance, codominance, lethal alleles, and epistasis




    • Sex-linked inheritance, pedigree analysis, and genetic mapping






  • Cytogenetics and Chromosomal Biology





    • Karyotyping and chromosome morphology




    • Chromosomal aberrations: Aneuploidy, polyploidy, deletions, duplications, inversions, and translocations




    • Meiotic recombination, non-disjunction, and crossing over






  • Gene Regulation and Epigenetics





    • Prokaryotic gene regulation (operon models like lac and trp)




    • Eukaryotic transcriptional regulation, chromatin remodeling, and pioneer factors




    • Epigenetic mechanisms: DNA methylation, genomic imprinting, and X-chromosome inactivation






  • Population and Evolutionary Genetics





    • Hardy-Weinberg equilibrium and forces causing deviation (mutation, migration, genetic drift, natural selection)




    • Quantitative genetics: Polygenic traits, heritability, and QTL mapping




    • Molecular evolution, phylogenetic analysis, and speciation







3. Cellular Biology: Structure, Function, and Dynamics



Cell biology studies the structural components of cells, how they maintain homeostasis, and how they interact with their environment.





  • Cellular Membranes and Transport





    • Fluid mosaic model, lipid raft composition, and membrane fluidity




    • Passive transport (simple and facilitated diffusion, osmosis)




    • Active transport (primary/secondary active transport, endocytosis, exocytosis)






  • Organelle Structure and Function





    • Nucleus: Nuclear envelope, pore complexes, and nucleolus




    • Endomembrane system: Rough/smooth endoplasmic reticulum, Golgi apparatus, and lysosomes




    • Energy transducers: Mitochondria (oxidative phosphorylation) and Chloroplasts (photosynthesis)




    • Peroxisomes, vacuoles, and proteasomes






  • Cytoskeleton and Cellular Motility





    • Microtubules, microfilaments (actin), and intermediate filaments




    • Motor proteins (kinesin, dynein, myosin) and intracellular transport




    • Cilia, flagella, and cell migration mechanisms






  • Cell Signaling and Communication





    • Types of signaling (autocrine, paracrine, endocrine, juxtacrine)




    • Receptor classes: G-protein coupled receptors (GPCRs), Receptor Tyrosine Kinases (RTKs), ion channel receptors, and intracellular receptors




    • Second messengers (cAMP, Ca2+, IP3/DAG) and kinase cascades (MAPK, PI3K/Akt)







4. Interrelated and Interdisciplinary Subtopics



These topics represent the massive overlap where molecular mechanisms directly dictate cellular behavior and genetic outcomes.





  • The Cell Cycle, Mitosis, and Meiosis





    • Phases of the cell cycle (G1, S, G2, M)




    • Cell cycle checkpoints (G1/S, G2/M, spindle assembly) and cyclins/CDKs




    • Mechanisms of mitosis (somatic division) vs. meiosis (germline division and genetic diversity)






  • Cell Death, Aging, and Cancer Biology





    • Apoptosis (intrinsic and extrinsic pathways), necrosis, and autophagy




    • Cellular senescence, telomere shortening, and aging




    • Oncogenes, tumor suppressor genes (e.g., p53, Rb), and the hallmarks of cancer (metastasis, angiogenesis)






  • Developmental Biology and Stem Cells





    • Cell potency: Totipotency, pluripotency, multipotency




    • Embryonic stem cells vs. induced pluripotent stem cells (iPSCs)




    • Morphogens, homeobox (Hox) genes, and pattern formation during development






  • Immunology and Host-Pathogen Interactions





    • Innate vs. adaptive immunity at the cellular level (T-cells, B-cells, macrophages)




    • V(D)J recombination (genetic rearrangement for antibody diversity)




    • Viral replication cycles and bacterial defense systems (e.g., CRISPR-Cas systems in nature)






  • Genomics, Proteomics, and Biotechnology





    • Recombinant DNA technology, cloning, and PCR




    • Next-Generation Sequencing (NGS) and functional genomics




    • Genome editing technologies (CRISPR-Cas9, base editing)




    • Bioinformatics, comparative genomics, and systems biology